Angiopoietin‐1 is an apoptosis survival factor for endothelial cells

FEBS Letters

Koh, Gou Young¹  Kim, Injune¹  Lee, Song Jae²  So, June-No³  Kwak, Hee Jin¹ 

[1] National Creative Research Initiatives Center for Cardiac Regeneration and Institute of Cardiovascular Research, Chonbuk National University School of Medicine, San 2-20, Keum-Am-Dong, Chonju 560-180, South Korea;Department of Radiology, Sohae College, Kunsan, South Korea;Department of Biotechnology, Woosuk University, Chonju, South Korea

关键词: Angiopoietin;    Apoptosis;    Endothelial cell;    VEGF;    vascular endothelial growth factor;    CMV;    cytomegalovirus;    cDNA;    complementary deoxyribonucleic acid;   

DOI  :  10.1016/S0014-5793(99)00378-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We examined the effect of angiopoietin-1 (Ang1) on apoptosis in human umbilical vein endothelial cells (HUVECs). Ang1 (5–1000 ng/ml) dose-dependently inhibited apoptosis under a serum-deprived state. A significant apoptotic inhibition occurred with as low as 50 ng/ml. Two hundred ng/ml of Ang1 inhibited to approximately 50% of the control apoptotic rates for 96 h. Furthermore, an augmented antiapoptotic effect of Ang1 by the addition of 20 ng/ml vascular endothelial growth factor was observed. This Ang1-induced strong antiapoptotic effect in endothelial cells is a novel and intriguing finding and could be an additional description of Ang1-induced direct biological function.

【 授权许可】

Unknown