In the rat, tumor necrosis factor α administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine‐induced thermogenesis?

FEBS Letters

López-Soriano, Francisco J²  Alvarez, Belén²  Argilés, Josep M²  Busquets, Sı́lvia²  Ricquier, Daniel¹  Sanchı́s, Daniel¹ 

[1] Centre National de la Recherche Scientifique, UPR 9078, 9 rue Jules Hetzel, 992190 Meudon, France;Departament de Bioquı́mica i Biologia Molecular, Unitat B, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain

关键词: Thermogenesis;    Tumor necrosis factor α;    Skeletal muscle;    Uncoupling protein 2;    Uncoupling protein 3;   

DOI  :  10.1016/S0014-5793(98)01485-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Since the discovery of the new members of the UCP (uncoupling protein) family, UCP2 and UCP3, very few studies have dealt with the regulation of their expression. Bearing this in mind, administration of a single intravenous injection of TNF-α (100 μg/kg body weight) to rats resulted in a significant increase in UCP2 (242%) and UCP3 (113%) gene expression in skeletal muscle. The results suggest a possible role for UCP2 and UCP3 in the increase of energy expenditure associated with cytokine treatment.

【 授权许可】

Unknown