Stress‐induced expression of transcriptional repressor ICER in the adrenal gland

FEBS Letters

Sassone-Corsi, Paolo¹  Foulkes, Nicholas S¹  Della Fazia, Maria Agnese¹  Servillo, Giuseppe¹ 

[1] Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP, B.P. 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France

关键词: Inducible cAMP early repressor;    cAMP-responsive element modulator;    Adrenocorticotropin hormone;    Adrenal gland;    Surgery;    Stress;    HPA;    hypothalamo-pituitary-adrenal;    cAMP;    cyclic adenosine monophosphate;    ICER;    inducible cAMP early repressor;    ACTH;    adrenocorticotropin hormone;    CRE;    cAMP-responsive element;    CREM;    CRE modulator;    NGF;    nerve growth factor;    bZip;    basic domain-leucine zipper;   

DOI  :  10.1016/S0014-5793(98)00944-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Second messenger cyclic AMP plays a central role in signalling within the hypothalamo-pituitary-adrenal (HPA) axis. Changes in gene expression are central to long-term adaptations made in response to stress in the adrenal gland. Here we demonstrate that expression of the cAMP inducible transcriptional repressor, ICER (Inducible cAMP Early Repressor), is rapidly and powerfully induced in response to surgical stress in the rat adrenal gland. Hypophysectomisation blocks stress-induced ICER expression. Finally we demonstrate that injection of the pituitary hormone ACTH (Adrenocorticotropin Hormone) induces robust ICER expression in the adrenal cortex. Thus, induction of the transcriptional repressor ICER is coupled to the HPA axis response to stress.

【 授权许可】

Unknown