The CRH‐ACTH‐biogenic amine axis in invertebrate immunocytes activated by PDGF and TGF‐β

FEBS Letters

Caselgrandi, Eva³  Kletsas, Dimitris²  Ottaviani, Enzo¹ 

[1] Department of Animal Biology, University of Modena, via Berengario, 14, 41100 Modena, Italy;Institute of Biology, National Center for Scientific Research `Demokritos', Athens 15310, Greece;Department of Biomedical Sciences, Hygiene and Microbiology Section, University of Modena, via Campi, 287, 41100 Modena, Italy

关键词: Platelet-derived growth factor AB;    Transforming growth factor-β1;    Adrenocorticotropin hormone;    Corticotropin-releasing hormone;    Interleukin-1α;    Biogenic amine;    Invertebrate immunocyte;    Stress response;    High-performance liquid chromatography;   

DOI  :  10.1016/S0014-5793(98)00438-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In immunocytes from the mollusc Mytilus galloprovincialis, the major pathway followed by platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-β1 in provoking the release of norepinephrine, epinephrine and dopamine into cell-free hemolymph (serum) is mediated by a corticotropin-releasing hormone-adrenocorticotropin hormone (CRH-ACTH) biogenic amine axis. This axis not only annulled the inhibiting properties of PDGF-AB, it even reversed the latter's effect, while the inducing effect of TGF-β1 was amplified. These findings show that non-classical immune-neuroendocrine molecules, such as PDGF-AB and TGF-β1, are involved in building stress response, using the same conserved mechanisms present from invertebrates to vertebrates.

【 授权许可】

Unknown