Superoxide dismutase activation in thyroid and suppression in adrenal Novel pituitary regulatory routes

FEBS Letters

Verma, Saguna¹  Nivsarkar, Manish¹  Singh, Apurna¹  Pradeep, Kumar G.¹  Laloraya, Malini¹ 

[1] School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Khandwa Road, Indore, M.P. 452 001, India

关键词: TSH;    SOD activity;    Adrenal gland;    Thyroglobulin iodination;    TSH;    thyroid stimulating hormone;    SOD;    superoxide dismutase;    ACTH;    adrenocorticotropin hormone;    H2O2;    hydrogen peroxide;    O.− 2;    superoxide anion radical;   

DOI  :  10.1016/0014-5793(91)80502-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This study reports that administration of TSH in young female mice results in a concomittant augmentation of SOD activity in the thyroid gland. A strong thyroid-adrenal interdependence was also evident in the form of a marked loss of SOD activity in the adrenal gland in response to TSH administration. Very recently SOD/O^.− ₂ system had been identified as a potent H₂O₂ generator which provides substrate for the action of key enzyme in thyroxine and progesterone biosynthesis, viz, the peroxidase. Thus, these results strongly suggest that trophic hormones tonically stimulate hormone biosynthesis by modulating activation/suppression of specific enzymes, which could be the basis of the tuning sequence.

【 授权许可】

Unknown