Composite pheochromocytoma of the adrenal gland: a case series

BMC Research Notes

Hideki Sakai¹  Toru Onita¹  Kousuke Takehara¹  Tomoaki Hakariya¹  Kuniko Abe²  Tsukasa Igawa¹  Yohei Shida¹ 

[1] Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan;Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan

关键词: Ki67;    Hemodialysis;    Adrenal gland;    Ganglioneuroma;    Ganglioneuroblastoma;    Composite pheochromocytoma;   

Others  :  1231711
DOI  :  10.1186/s13104-015-1233-6

 received in 2014-03-20, accepted in 2015-06-16,  发布年份 2015

【 摘 要 】

Background

Composite pheochromocytoma is a rare pathological condition characterized by elements of both pheochromocytoma and neurogenic tumors. However, detailed clinical outcomes of this tumor have not been fully shown. From 2007 to 2013, we experienced three cases of adrenal composite pheochromocytoma. In this report, we investigate the clinicopathological features of these three cases of composite pheochromocytoma and compare them with previously reported cases.

Case presentations

Cases 1 and 2 were a 29-year-old Japanese woman and a 59-year-old Japanese man, respectively. They underwent laparoscopic left adrenalectomy, and pathological examination revealed composite pheochromocytoma–ganglioneuroma. Case 3 was a 53-year-old Japanese man who had been receiving hemodialysis for 17 years. He underwent laparoscopic right adrenalectomy, and pathological examination revealed composite pheochromocytoma–ganglioneuroblastoma. Although the Ki67-positive rates varied from 1.0 to 6.2% among the three cases, no clinical recurrences occurred. Despite the relatively high rate of Ki67 positivity, complete tumor resection resulted in favorable clinical outcomes.

Conclusion

We experienced three cases of adrenal composite pheochromocytoma. Although the clinical findings and treatment outcomes of composite pheochromocytoma were similar to those of ordinary pheochromocytoma, further studies of the biological behavior and genetic profiles of composite pheochromocytoma are necessary to achieve a better understanding of this tumor.

【 授权许可】

   
2015 Shida et al.

【 图 表 】

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