Regulation of the type II oncostatin M receptor expression in lung‐derived epithelial cells

FEBS Letters

Puré, Ellen¹  Cichy, Joanna²  Rose-John, Stefan³ 

[1] The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA;Department of Microbiology and Immunology, Institute of Molecular Biology, Jagiellonian University, 31-120 Cracow, Poland;Department of Medicine, Johannes Gütenberg University, D-55101 Mainz, Germany

关键词: Interleukin-6;    Leukemia inhibitory factor;    Transforming growth factor β1;    Bronchial epithelium;    OSM;    oncostatin M;    LIF;    leukemia inhibitory factor;    IL-6;    interleukin-6;    IL-1;    interleukin-1;    FBS;    fetal bovine serum;    MEM;    minimal essential medium;   

DOI  :  10.1016/S0014-5793(98)00643-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oncostatin M (OSM) is a potent modulator of human lung-derived epithelial cell function. This cytokine binds two distinct receptor complexes: type I OSM receptor which is also a functional receptor for leukemia inhibitory factor (LIF), and type II OSM-specific receptor. The role of these two distinct receptors in mediating the response of individual cell types to OSM has not been delineated. In contrast to LIF, OSM induces synthesis of α₁-antichymotrypsin and α₁-antiproteinase inhibitor in lung-derived epithelial cells. The differential responsiveness to LIF and OSM suggested that the response of lung epithelial cells to OSM may be mediated by the OSM-specific receptor. Therefore, we characterized lung-derived epithelial cells for the expression of type II OSM receptor mRNAs, and the regulation of the mRNAs encoding the components of the OSM-specific receptor by cytokines and dexamethasone.

【 授权许可】

Unknown