Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes

FEBS Letters

Yazaki, Yoshio¹  Aikawa, Ryuichi¹  Nagai, Ryozo¹  Saito, Shuichi¹  Komuro, Issei¹  Shiojima, Ichiro¹ 

[1] Department of Cardiovascular Medicine, University of Tokyo Gradulate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

关键词: Endothelin-1;    Interleukin-6;    Leukemia inhibitory factor;    Atrial natriuretic peptide;    Brain natriuretic peptide;    β-Type myosin heavy chain;   

DOI  :  10.1016/S0014-5793(99)00936-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We here examined the role of the interleukin-6 (IL-6) family of cytokines in endothelin-1 (ET-1)-induced hypertrophic responses using cultured cardiac myocytes of neonatal rats. ET-1 induced expression of IL-6 and leukemia inhibitory factor (LIF) genes. ET-1-induced LIF gene expression was abolished by inhibition of protein kinase C activity. ET-1 activated the promoter of atrial natriuretic peptide and β-type myosin heavy chain genes through the tyrosine kinase pathway and IL-6 receptor gp130. These results suggest that the IL-6 family of cytokines mediates ET-1-induced expression of some fetal genes in cardiac myocytes.

【 授权许可】

Unknown