Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells

FEBS Letters

Belinsky, Steven A²  Pryor, William A¹  Lechner, John F²  Kennedy, Christopher H¹  Cueto, Rafael¹ 

[1] Biodynamics Institute, 711 Choppin Hall, Louisiana State University, Baton Rouge, LA 70803, USA;Lovelace Respiratory Research Institute, Albuquerque, NM, USA

关键词: Human MutT homologue;    Gene expression;    Lung cancer;    Molecular marker;    Oxidative stress;    8-Oxo-deoxyguanosine;   

DOI  :  10.1016/S0014-5793(98)00505-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human MutT homologue (hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine. Together, these results suggest that hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer.

【 授权许可】

Unknown