Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas

FEBS Letters

Hanash, Samir¹  Creighton, Chad²  Beer, David³ 

[1] Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA;Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA;Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA

关键词: Gene expression;    Lung cancer;    Differentiation;    Microarray;   

DOI  :  10.1016/S0014-5793(03)00259-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An analysis of microarray data from 86 lung adenocarcinomas reveals hundreds of genes significantly correlated with tumor cell differentiation. A bioinformatics approach of linking these genes to public information from the Locuslink and KEGG databases yields evidence for a loss of tumor cell differentiation being associated with biological processes of cell division, protein degradation, pyrimidine and purine metabolism, oxidative phosphorylation, glyoxylate and dicarboxylate metabolism, folate biosynthesis, and glutamate metabolism. The increased expression of genes involved in these processes is consistent with increased proliferation and metabolism characteristics of poorly differentiated tumors. The complete results of this analysis are available at http://dot.ped.med.umich.edu:2000/pub/diff/index.htm.

【 授权许可】

Unknown