Existence of four acetylcholinesterase genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae

FEBS Letters

Toutant, Jean-Pierre¹  Combes, Didier¹  Arpagaus, Martine¹  Culetto, Emmanuel¹  Fedon, Yann¹  Grauso, Marta¹ 

[1] Groupe `Cholinestérases', Différenciation cellulaire et Croissance, Centre INRA de Montpellier, 2 place Viala, 34060 Montpellier cedex 1, France

关键词: Acetylcholinesterase;    Caenorhabditis elegans;    Caenorhabditis briggsae;    AChE;    acetylcholinesterase;    ace-1;    ace-2;    ace-3 and ace-4;    genes encoding AChE of classes A;    B;    C and D;   

DOI  :  10.1016/S0014-5793(98)00191-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Three genes, ace-1, ace-2 and ace-3, respectively located on chromosomes X, I and II, were reported to encode acetylcholinesterases (AChEs) of classes A, B and C in the nematode Caenorhabditis elegans. We have previously cloned and sequenced ace-1 in the two related species C. elegans and C. briggsae. We report here partial sequences of ace-2 (encoding class B) and of two other ace sequences located in close proximity on chromosome II in C. elegans and C. briggsae. These two sequences are provisionally named ace-x and ace-y, because it is not possible at the moment to establish which of these two genes corresponds to ace-3. Ace-x and ace-y are transcribed in vivo as shown by RT-PCR and they are likely to be included in a single operon.

【 授权许可】

Unknown