TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

FEBS Letters

Wei, Ying-Fei¹  Dixit, Vishva M²  Ni, Jian¹  Yu, Guo-liang¹  Pan, Guohua² 

[1] Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850-3338, USA;Department of Pathology, University of Michigan Medical School, MSRBI, Room 7520, 1301 Catherine Road, Ann Arbor, MI 48109, USA

关键词: Tumor necrosis factor receptor;    TRAIL receptor;    Apoptosis;    Death domain;    Decoy receptor;   

DOI  :  10.1016/S0014-5793(98)00135-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells.

【 授权许可】

Unknown