Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor

FEBS Letters

Yu, Guoliang³  Liu, Ding³  Dixit, Vishva M¹  Haridas, Valsala²  Aggarwal, Bharat B²  Vincenz, Claudius¹  Bauer, Johannes H¹  Wang, Shuxia³  Ni, Jian³  Pan, Guohua¹ 

[1] Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA;Cytokine Research Section, Department of Molecular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;Human Genome Sciences, Inc., 9410 Key West Avenue, Rockville, MD 20850-3338, USA

关键词: Tumor necrosis factor receptor;    Death receptor;    Death domain;    Nuclear factor κB;    JNK;   

DOI  :  10.1016/S0014-5793(98)00791-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Tumor nectosis factor (TNF) receptors are key players in inflammation and immune regulation. A new member of this family, termed death receptor-6 (DR6), has been identified. Like other death receptors, DR6 is a type I transmembrane receptor, possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is expressed in most human tissues and abundant transcript was detected in heart, brain, placenta, pancreas, thymus, lymph node and several non-lymphoid cancer cell lines. DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-κB and JNK.

【 授权许可】

Unknown