T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK

FEBS Letters

Garcia, Daniel E.¹  Dadgostar, Hajir²  Doyle, Sean E.¹  Cheng, Genhong³  Shahangian, Arash² 

[1] Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA;Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA 90095, USA;Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA

关键词: Tumor necrosis factor receptor-associated factor 3;    Tumor necrosis factor receptor;    Jun N-terminal kinase;    Nuclear factor κB;    Subcellular localization;    Signal transduction;   

DOI  :  10.1016/S0014-5793(03)01072-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-κB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation.

【 授权许可】

Unknown