Protective effects of the lipophilic redox conjugate tocopheryl succinyl‐ethyl ferulate on HIV replication

FEBS Letters

Vergnes, Laurent²  Claise, Catherine¹  Lindenbaum, Albert¹  Barthelemy, Sophie²  Edeas, Marvin A¹  Labidalle, Serge² 

[1] Département de Biochimie, Hôpital Antoine Béclère, 157 rue de la Porte de Trivaux, 92141 Clamart, France;Laboratoire de Synthèse, Physicochimie et Radiologie, Faculté de Pharmacie, Université de Toulouse III, 31062 Toulouse, France

关键词: Human immunodeficiency virus;    Oxidative stress;    Phenolic compound;    Vitamin E;    Lipophilic drug;    HIV;    human immunodeficiency virus;    PHA;    phytohemagglutinin;    PBMC;    peripheral blood mononuclear cell;    TNFα;    tumor necrosis factor alpha;    ROS;    reactive oxygen species;    MDM;    monocyte-derived macrophages;   

DOI  :  10.1016/S0014-5793(97)01335-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound.

【 授权许可】

Unknown