Neokyotorphin and neokyotorphin (1–4): secretion by erythrocytes and regulation of tumor cell growth

FEBS Letters

Karelin, Andrei A¹  Ziganshin, Rustam H¹  Mernenko, Olga A¹  Blishchenko, Elena Yu¹  Yatskin, Oleg N¹  Philippova, Marina M¹  Ivanov, Vadim T¹ 

[1] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 Moscow, GSP-7, Russia

关键词: Neokyotorphin;    Erythrocytes primary culture;    Tumor cell;    Proliferation;   

DOI  :  10.1016/S0014-5793(97)00991-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human erythrocytes release neokyotorphin, the 137–141 fragment of hemoglobin α-chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1–4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1–4 fragment were shown to stimulate proliferation of L929 tumor cells.

【 授权许可】

Unknown