Neuroprotective potential of aromatic alcohols against oxidative cell death

FEBS Letters

Behl, Christian¹  Moosmann, Bernd¹  Uhr, Manfred¹ 

[1] Max-Planck-Institute of Psychiatry, Clinical Institute, Kraepelinstrasse 10, 80804 Munich, Germany

关键词: Aromatic alcohol;    Glutamate;    Oxidative stress;    Neurodegeneration;    Lipid peroxidation;    Antioxidant;   

DOI  :  10.1016/S0014-5793(97)00961-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Estrogens can protect neurons against oxidative stress-induced cell death due to their antioxidant potential. Here, we report that other aromatic alcohols with intact phenolic groups and different phenol derivatives can also protect neurons against oxidative cell death induced by glutamate and hydrogen peroxide in vitro. This neuroprotective activity was independent of the time the compound was added before the toxin. Methylation of the phenolic hydroxyl group led to a decrease or loss in neuroprotection. Moreover, the tested compounds directly inhibited peroxidation reactions, suggesting that neuroprotection is mediated by their antioxidant properties.

【 授权许可】

Unknown