A novel putative G‐protein‐coupled receptor expressed in lung, heart and lymphoid tissue

FEBS Letters

Kvingedal, Ane M¹  Smeland, Erlend B¹ 

[1] Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway

关键词: G-protein-coupled receptor;    Lymphocyte;    Hematopoietic progenitor cell;    PCR;    polymerase chain reaction;    BLR1;    Burkitt's lymphoma receptor 1;    IL-8;    interleukin 8;    TM;    transmembrane;    ATCC;    American Type Culture Collection;    DSM;    German Collection of Microorganisms and Cell Cultures;   

DOI  :  10.1016/S0014-5793(97)00278-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

cDNA encoding a novel putative G-protein-coupled receptor, named LyGPR ( mphocyte derived- rotein-coupledeceptor) was cloned using a reverse transcription-PCR approach. The LyGPR amino acid sequence is 375 residues long and shows similarity (about 30–35% identity) both to the angiotensin receptors and members of the chemokine receptor family. Northern blot analysis revealed a 3.1-kb LyGPR transcript expressed predominantly in lung, heart and lymphoid tissues. LyGPR expression was also detected in the pre-B acute lymphoblastoid leukemia cell lines Reh and Nalm-6, in the Burkitt's lymphoma line Daudi, and in hematopoietic progenitor cells from bone marrow, as well as in B cells, T cells and monocytes from peripheral blood.

【 授权许可】

Unknown