Scavengase p20: a novel family of bacterial antioxidant enzymes

FEBS Letters

Hou, Yun-De¹  Jin, Dong-Yan¹  Wang, Hai-Lin¹  Wan, Xiao-Yu¹  Zhou, Yuan¹  Yan, Zi-Ying¹ 

[1] National Key Laboratory of Molecular Biology and Genetic Engineering, Chinese Academy of Preventive Medicine, 100 Yingxin Street, Beijing 100052, People's Republic of China

关键词: Scavengase p20;    Antioxidant enzyme;    Thioredoxin-dependent peroxidase;    Helicobacter pylori;    Sequence analysis;    Protein microsequencing;   

DOI  :  10.1016/S0014-5793(97)00302-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel antioxidant enzyme designated scavengase p20 was identified in various pathogenic bacteria through database searching for sequences strikingly homologous to a recently discovered Escherichia coli thiol peroxidase p20. The direct biochemical evidence for the existence of scavengase p20 in Haemophilus influenzae, Streptococcus pneumoniae and Helicobacter pylori was provided by protein microsequencing and by in vitro assays for antioxidant activities. Overlapping genes encoding scavengase p20 and superoxide dismutase were recognized in H. pylori and their functional implications are discussed.

【 授权许可】

Unknown