The carotenoids β‐carotene, canthaxanthin and zeaxanthin inhibit macrophage‐mediated LDL oxidation

FEBS Letters

Dennis, Ian F¹  Mitchinson, Malcolm J¹  Hird, Rachel¹  van der Veen, Carina¹  Ding, Tina¹  Carpenter, Keri L.H¹ 

[1] Division of Cellular Pathology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK

关键词: Carotenoid;    β-Carotene;    Zeaxanthin;    Canthaxanthin;    Low-density lipoprotein;    Monocyte-macrophage (human);   

DOI  :  10.1016/S0014-5793(96)01488-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human monocyte-macrophages were incubated for 24 h in Ham's F-10 medium with human low-density lipoprotein (LDL) in the presence or absence of β-carotene, canthaxanthin or zeaxanthin, at final concentrations of 2.5, 12.5 and 25 mg/l. LDL oxidation, measured by agarose gel electrophoresis, the thiobarbituric acid assay and gas chromatography, was inhibited by each of the carotenoids in a concentration-dependent manner. Canthaxanthin was more effective when incorporated into LDL before addition to the cultures whereas β-carotene and zeaxanthin were more effective when added simultaneously with LDL. The results suggest that dietary carotenoids might help slow atherosclerosis progression.

【 授权许可】

Unknown