Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum

FEBS Letters

Misquith, Sandra²  Surolia, Namita¹ 

[1] Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore-560 064, India;Department of Chemistry, St. Joseph's College, Bangalore, India

关键词: Plasmodium falciparum;    Toxin;    Ribosome inactivating protein;    Gelonin-transferrin conjugate;    Targeting;    IRBC;    infected red blood cells;    URBC;    uninfected red blood cells;    RIP;    ribosome inactivating protein;    SMCC;    N-succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate;    EMEM;    Eagle's minimal essential medium;    Tf;    transferrin;    [125I]Tf[Fe2+];    odinated holotransferrin;    PBS;    phosphate buffered saline;    SDS-PAGE;    sodium dodecyl sulfate-polyacrylamide gel electrophoresis;   

DOI  :  10.1016/0014-5793(96)01065-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Gelonin (a toxin and type II ribosome inactivating protein) when linked to human transferrin can be targeted to Plasmodium falciparum. The transferrin toxin conjugate is significantly toxic to parasite growth and is 25 times more potent than toxin alone in inhibiting parasite protein synthesis. The mechanism of its entry into the intraerythrocytic parasite is discussed.

【 授权许可】

Unknown