Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment

FEBS Letters

Caputi, Antonio¹  Luca, Monica Di¹  Pastorino, Lucia¹  Cattabeni, Flaminio N.¹  Cimino, Mauro¹  Rurale, Sabrina¹ 

[1] Inst. Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy

关键词: Protein kinase C;    Translocation;    Synaptic plasticity;    CA;    cornu ammonis;    LTP;    long-term potentiation;    MAM;    methylazoxymethanol;    NMDA;    N-methyl-d-aspartate;    PKC;    protein kinase C;    PMSF;    phenylmethylsulfonyl fluoride;   

DOI  :  10.1016/0014-5793(96)00846-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The translocation of protein kinase C isozymes was investigated in an animal model of cognitive deficit and lack of induction of long-term potentiation (LTP). In MAM rats, presynaptic α, β, ϵ PKC showed enhanced translocation, while postsynaptic γ PKC displayed decreased translocation when compared to control levels. This imbalance of PKC isozyme translocation between the pre- and post-synaptic compartment might therefore represent a possible molecular cause for the lack of synaptic plasticity observed in these animals.

【 授权许可】

Unknown