Antioxidant properties of omeprazole

FEBS Letters

Gioia, Sergio de¹  Lapenna, Domenico¹  Cuccurullo, Franco¹  Ciofani, Giuliano¹  Festi, Davide¹ 

[1] Istituto di Fisiopatologia Medica, Universitá degli Studi ‘G. D'Annunzio’, Facoltá di Medicina e Chirurgia, Via dei Vestini, 66100 Chieti, Italy

关键词: Omeprazole;    Hypochlorous acid;    Iron;    Copper;    Oxidative stress;    Antioxidant;   

DOI  :  10.1016/0014-5793(96)00155-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 μM at pH of 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCl scavenger ascorbate. Moreover, 10 and 50 μM OM inhibit significantly both iron-and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.

【 授权许可】

Unknown