Effectiveness differences of ranitidine and omeprazole in prevention of stress ulcer and its effect on pneumonia occurrence and outcome of acute stroke patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Batubara, C.A.^1 ; Ritarwan, K.^1 ; Rambe, A.S.^1

Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Jalan Bunga Lau No 17, Medan Tuntungan, Kota Medan, Sumatera Utara

20136, Indonesia^1

关键词: Acute stroke;    Control groups;    Modified Rankin Scale;    National Institutes of Health;    Omeprazole;    Ranitidine;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012205/pdf
DOI  :  10.1088/1755-1315/125/1/012205

来源: IOP

【 摘 要 】

Stress ulcer is one ofacute stroke complications. Giving ranitidine or omeprazole may prevent stress ulcer, but may increase the occurrence of pneumonia. Thus, it will affect the outcome of acute stroke. The method was experimental with a randomized control-group pretest - posttest design. This study divided the subjects into two groups, ranitidine 300mg and omeprazole 20mg group.We observed the patients whether stress ulcer or pneumonia occurred during hospitalization. Then, we measured the outcome by the National Institutes of Health Stroke Scaleand modified Rankin Scale. There were 32 subjects in this study. Only 1 (3.1%) subject suffered stress ulcer, and 3 (3.1%) suffered pneumonia in ranitidine group. Moreover, 2 (6.2%) subjects suffered pneumonia in omeprazole group. The differences were not significant between the two groups (p = 0.31 and p = 0.54). There was no significant effect and difference effect on the administration of both medications to the outcome at day 14. These results indicate that ranitidine and omeprazole have anequal effectiveness in the prevention of stress ulcer and also have equal effect on the occurrence of pneumonia, and both have no effect on the outcome of acute stroke patients.