Toxic Effect of Aflatoxin B1 on Heart, Lung, and Testis of Male Albino Rats: Histopathology Study

2nd International Scientific Conference (Pure Sciences, Brilliant Creativity and Renewed Building)

Kudayer, Alia M.^1 ; Alsandaqchi, Alaa T.A.^2 ; Saleh, Faleah M.^3 ; Alwan, Nawras A.^4

Anatomy and Histology Department, Veterinary Medicine College, University of Basrah, Iraq^1

Veterinary Public Health Department, Veterinary Medicine College, University of Basrah, Iraq^2

Food Science Department, Agricultural College, University of Basrah, Iraq^3

Physiology, Pharmacology and Biochemistry Department, Veterinary Medicine College, University of Basrah, Iraq^4

关键词: Control groups;    Deleterious effects;    Distilled water;    Histological examination;    Histological structure;    Inflammatory cells;    Internal organs;    Vacuolated cells;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/571/1/012055/pdf
DOI  :  10.1088/1757-899X/571/1/012055

来源: IOP

【 摘 要 】

The current study was carried out to investigate the toxic effects of aflatoxin B1 exposure on heart, lung, and testis of male Albino rats. Twelve healthy male Albino rats were used in the current study. They were divided equally into 2 groups (control and treated groups). The treated group was given aflatoxin B1 orally by a gastric tube at concentration 0.5 mg per kg of body weight for 7 day. The control group was given distilled water alone. At the end of experiment (1 week), the rats were killed under ether anesthesia and the internal organs(heart, lung, and testis) were collected immediately for histological examination. The histopathology examination in heart revealed that there is oedema between myocardial. In lung, there is a large number of inflammatory cells and dilated the alveolar sac with exudates. The testis revealed the excessive vacuolated cells and suppression spermatogenesis. In conclusion, oral dose of aflatoxin B1 exposure could induce a deleterious effect on the histological structure of the heart, lung, and testis of male Albino rats. High level of attention must be taken to prevent the possible contamination of our food with aflatoxin B1.