Nitric oxide synthase in chick embryo retina during development

FEBS Letters

Naso, Antonio¹  Picciurro, Vincenzo¹  Macaione, Salvatore¹  Pedale, Santa¹  Ientile, Riccardo¹  Malecka, Bozena¹ 

[1] Institute of Biochemical Sciences and Clinical Biochemistry, Faculty of Medicine, University of Messina, Messina, Italy

关键词: Nitric oxide synthase;    Chick embryo;    Retina;    Development;    NMDA;    NO;    nitric oxide;    NOS;    nitric oxide synthase;    NMDA;    N-methyl-d-aspartate;    l-NA;    Nω-nitro-l-arginine;    d-NA;    Nω-nitro-d-arginine;    EGTA;    ethylene glycolbis(β-aminoethyl ether) N;    N;    N′;    N′-tetracetic acid;   

DOI  :  10.1016/0014-5793(95)01490-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

High levels of nitric oxide synthase were found in the early stages of developing chick embryo retina. The enzyme activity sharply decreased up to 13-day-old chick embryo retina, when the level of the last embryonic day was reached. The results show that nitric oxide is synthesized in chick embryo retina prior to synaptogenesis. The incubation of chick embryo retinas in presence of NMDA increased the synthesis of nitric oxide, thus, the appearance of nitric oxide production before the synaptogenesis in the retina as well as in the brain may be considered as signal for the development and shaping of neuronal and non-neuronal cells.

【 授权许可】

Unknown