A growth inhibitor implicated in the growth arrest of human fibroblasts

FEBS Letters

Macieira-Coelho, A.¹ 

[1]INSERM and University of Paris VI, 73 bis rue Marechal Foch, 78000 Versailles, France

关键词: Human fibroblast;    Growth inhibitor;    Negative growth factor;    Growth regulation;   

DOI  :  10.1016/0014-5793(95)01426-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

When quiescent human fibroblasts are induced to divide, the sugar composition of a growth inhibitory glycoprotein is modified. The kinetics of the incorporation of glucosamine in the growth inhibitor follows the kinetics of cell growth. It increases as cells approach quiescence and declines when cells initiate proliferation. The results suggest that the modification of the sugar composition of this glycoprotein is coupled with the variation of its inhibitory potential and this way to the initiation and the arrest of cell division.

【 授权许可】

Unknown