Effect of a mammary‐derived growth inhibitor on the expression of the oncogenes c‐fos, c‐myc and c‐ras

FEBS Letters

Graetz, H.¹  Strauss, M.¹  Langen, P.¹  Kießling, U.¹  Koberling, A.¹  Lehmann, W.¹ 

[1] Central Institute for Molecular Biology, Academy of Sciences, Robert-Roessle-Str. 10, 1115 Berlin-Buch, GDR

关键词: Oncogene;    Growth inhibitor;    (Ehrlich ascites cell);   

DOI  :  10.1016/0014-5793(89)81189-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A mammary-derived growth inhibitor (MDGI) inhibits the resumption of growth of stationary Ehrlich ascites carcinoma (EAC) cells in vitro. The present study shows that the resumption of growth is accompanied by a rapid increase of the steady state mRNA level of the proto-oncogenes c-fos, c-myc and c-ras, which is reduced by MDGI. EAC cells from the exponential growth phase insensitive to MDGI did not show a reduced RNA expression. The effect of MDGI represents a novel activity at the level of gene expression and suggests a link to exist between growth inhibition and the reduction of c-fos, c-myc and c-ras expression.

【 授权许可】

Unknown