Calcium phosphate composite cements based on simple mixture of brushite and apatite phases

3rd International Youth Scientific Forum with International Participation "New Materials"

Egorov, A.A.^1 ; Fedotov, A. Yu^1 ; Pereloma, I.S.^1 ; Teterina, A. Yu^1 ; Sergeeva, N.S.^2 ; Sviridova, I.K.^2 ; Kirsanova, V.A.^2 ; Akhmedova, S.A.^2 ; Nesterova, A.V.^3 ; Reshetov, I.V.^4 ; Barinov, S.M.^1 ; Komlev, V.S.^1

Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow

119334, Russia^1

P.A. Herzen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, Ministry of Health Care of the Russian Federation, Moscow

125284, Russia^2

N.I. Pirogov Russian National Medical University, Ministry of Education and Science of the Russian Federation, Moscow

117997, Russia^3

I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow

119991, Russia^4

关键词: Biological tests;    Composite cements;    Human fibroblast;    Human osteosarcoma cells;    Kinetics of degradation;    Microstructure and mechanical properties;    Observation Period;    Simulated body fluids;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/347/1/012039/pdf
DOI  :  10.1088/1757-899X/347/1/012039

来源: IOP

【 摘 要 】

The composite cements based on simple mixtures brishite and apatite with ratio 70/30, 50/50, 30/70 were developed. The processes of phase formation, microstructure and mechanical properties were studied. The kinetics of degradation in simulated body fluid depending on the microstructure and the materials phase composition was carried out. The biological test in vitro were performed using the MTT-test on the human fibroblast immortalized (hFB) cell line and the human osteosarcoma cell line MG-63. The materials didn't have acute cytoxicity and possessed surface matrix properties. It was determined that the both line of cells actively proliferated, with viable cells values higher 20-60 % then control at all observation periods.