M‐caveolin, a muscle‐specific caveolin‐related protein

FEBS Letters

Way, Michael¹  Parton, Robert G.¹ 

[1] European Molecular Biology Laboratory, Meyerhofstrasse 1, D6901 Heidelberg, Germany

关键词: Caveolae;    Muscle;    VIP21-caveolin;    M-caveolin;    Membrane;    C2C12;   

DOI  :  10.1016/0014-5793(95)01256-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells. The best-characterised caveolar protein is the integral membrane protein, VIP21-caveolin. We now describe a novel homologue of VIP21-caveolin, M-caveolin, which is expressed exclusively in muscle. M-caveolin was shown to be expressed in differentiated myotubes but not myoblasts. Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin. M-caveolin may play a specialised role in the caveolae of muscle cells.

【 授权许可】

Unknown