Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery

FEBS Letters

Basu, Sandip K.¹  Mukhopadhyay, Bratati¹  Mukhopadhyay, Amitabha¹ 

[1] National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India

关键词: Multidrug resistance;    Scavenger receptor;    Endocytosis;    Drug targeting;    MDR;    multidrug resistance;    MBSA;    maleylated bovine serum albumin;    DNM;    daunomycin;    PgP;    P-glycoprotein;    PBS;    phosphate-buffered saline;    DXR;    doxorubicin;    Mtx;    methotrexate;    Vin;    vincristine;    5-Fu;    5-fluorouracil;    Mit;    mitomycin C;    FCS;    fetal calf serum;    TCA;    trichloroacetic acid;   

DOI  :  10.1016/0014-5793(95)01250-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A conjugate of the antineoplastic drug daunomycin (DNM) with maleylated bovine serum albumin (MBSA-DNM) was taken up with high efficiency by a multidrug resistant variant, JD100, of the murine-macrophage tumour cell line, J774A.1, through the scavenger receptors resulting in cessation of DNA synthesis. In contrast, free DNM at similar concentrations did not affect the incorporation of [³H]thymidine by these cells. These results suggest that receptor-mediated intracellular delivery of antineoplastic drugs could be a viable and new approach for overcoming the problem of multidrug resistance in chemotherapy of neoplastic diseases.

【 授权许可】

Unknown