FEBS Letters | |
Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis | |
Ben-Av, Pazit1  Wilder, Ronald L.2  Hla, Timothy1  Crofford, Leslie J.3  | |
[1] Department of Molecular Biology, Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA;NIAMS, NIH, Bethesda, MD, USA;Department of Internal Medicine, Division of Rheumatology, University of Michigan School of Medicine, Ann Arbor, MI, USA | |
关键词: Angiogenesis; Interleukin-1α; Prostaglandin E2; Rheumatoid arthritis; Vascular endothelial growth factor; IL-1α; interleukin-1; PGE1; prostaglandin E1; PGE2; prostaglandin E2; RA; rheumatoid arthritis; RT-PCR; reverse transcriptase-polymerase chain reaction; VEGF; vascular endothelial growth factor; | |
DOI : 10.1016/0014-5793(95)00956-A | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Inflammatory mediators such as prostaglandin E2 (PGE2) and interleukin-1 (IL-1) induce angiogenesis by yet undefined mechanisms. We demonstrate that PGE2 and IL-1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells. Transcripts for the EP1 and EP2, subtypes of PGE receptors are expressed in synovial fibroblasts. Activators of protein kinase A pathway stimulated the expression of VEGF whereas down-regulation of protein kinase C did not influence the PGE effect, suggesting that signalling from the EP2 receptor via the protein kinase A pathway is important. The induction of VEGF expression by PGE2 and interleukin-1α a may be an important mechanism in inflammatory angiogenesis.
【 授权许可】
Unknown
【 预 览 】
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