期刊论文详细信息
FEBS Letters | |
The first untranslated exon of the human tenascin‐C gene plays a regulatory role in gene transcription | |
Zardi, Luciano1  Ponassi, Marco1  Gherzi, Roberto1  Gaggero, Barbara1  | |
[1] Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV 10, 16132 Genoa, Italy | |
关键词: Tenascin-C; Gene transcription; Enhancer; Silencer; | |
DOI : 10.1016/0014-5793(95)00778-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The transcription of the human tenacin-C (TN-C) gene is directed by a single promoter. Here we demonstrate, in transiently transfected cells, that two distinct regions of the untranslated 179 bp-long exon 1 play antagonistic roles in transcriptional regulation: bases from 1 to 20 strongly increase the transcription of the reporter gene CAT directed by the human TN-C gene promoter, while bases from 79 to 179 significantly reduce this activation.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020301480ZK.pdf | 427KB | download |