The first untranslated exon of the human tenascin‐C gene plays a regulatory role in gene transcription

FEBS Letters

Zardi, Luciano¹  Ponassi, Marco¹  Gherzi, Roberto¹  Gaggero, Barbara¹ 

[1] Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV 10, 16132 Genoa, Italy

关键词: Tenascin-C;    Gene transcription;    Enhancer;    Silencer;   

DOI  :  10.1016/0014-5793(95)00778-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The transcription of the human tenacin-C (TN-C) gene is directed by a single promoter. Here we demonstrate, in transiently transfected cells, that two distinct regions of the untranslated 179 bp-long exon 1 play antagonistic roles in transcriptional regulation: bases from 1 to 20 strongly increase the transcription of the reporter gene CAT directed by the human TN-C gene promoter, while bases from 79 to 179 significantly reduce this activation.

【 授权许可】

Unknown