GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia

Biology Direct

Hedi Hegyi¹ 

[1] CEITEC—Central European Institute of Technology, Masaryk University, CZ-62500, Brno, Czech Republic

关键词: Silencer;    Enhancer;    GABA receptor;    GABBR1;    GABA;    LTR;    long terminal repeat;    HERV-W;    Human endogenous retrovirus;    Schizophrenia;   

Others  :  794953
DOI  :  10.1186/1745-6150-8-5

 received in 2012-12-10, accepted in 2013-02-04,  发布年份 2013

【 摘 要 】

Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.

【 授权许可】

   
2013 Hegyi; licensee BioMed Central Ltd.

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