Biology Direct | |
GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia | |
Hedi Hegyi1  | |
[1] CEITEC—Central European Institute of Technology, Masaryk University, CZ-62500, Brno, Czech Republic | |
关键词: Silencer; Enhancer; GABA receptor; GABBR1; GABA; LTR; long terminal repeat; HERV-W; Human endogenous retrovirus; Schizophrenia; | |
Others : 794953 DOI : 10.1186/1745-6150-8-5 |
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received in 2012-12-10, accepted in 2013-02-04, 发布年份 2013 | |
【 摘 要 】
Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
【 授权许可】
2013 Hegyi; licensee BioMed Central Ltd.
【 预 览 】
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