Biology Direct | 卷:8 |
GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia | |
关键词: Schizophrenia; Human endogenous retrovirus; HERV-W; long terminal repeat; LTR; GABA; GABBR1; GABA receptor; Enhancer; Silencer; | |
DOI : 10.1186/1745-6150-8-5 | |
来源: DOAJ |
【 摘 要 】
Abstract
Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
Reviewers
This paper was reviewed by Sandor Pongor and Martijn Huynen.
【 授权许可】
Unknown