FEBS Letters | |
COP‐coated vesicles in intracellular protein transport | |
Harter, Cordula1  | |
[1] Institut für Biochemie I, Universität Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany | |
关键词: Golgi membrane; Endoplasmic reticulum; Vesicle coat; Vesicle budding; Anterograde transport; Retrograde transport; | |
DOI : 10.1016/0014-5793(95)00621-F | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
COP-coated vesicles have originally been implicated in vesicular transport between subcompartments of the Golgi complex in mammals in a cis to trans direction. More recently, a role for COP-coated vesicles in transport between the endoplasmic reticulum (ER) and Golgi in mammalian cells has been proposed. Under certain conditions COP-coats have been localized to special domains of the transitional ER and to the cis side of the Golgi complex. This led to the assumption that COP-coated vesicles are involved in export of proteins from the ER. In addition, new findings point to a function of COP-coated vesicles in back transport of proteins from the Golgi to the ER. At present it is not known whether COP-coated vesicles move only in one or in both directions between ER and Golgi.
【 授权许可】
Unknown
【 预 览 】
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