COP‐coated vesicles in intracellular protein transport

FEBS Letters

Harter, Cordula¹ 

[1] Institut für Biochemie I, Universität Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany

关键词: Golgi membrane;    Endoplasmic reticulum;    Vesicle coat;    Vesicle budding;    Anterograde transport;    Retrograde transport;   

DOI  :  10.1016/0014-5793(95)00621-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

COP-coated vesicles have originally been implicated in vesicular transport between subcompartments of the Golgi complex in mammals in a cis to trans direction. More recently, a role for COP-coated vesicles in transport between the endoplasmic reticulum (ER) and Golgi in mammalian cells has been proposed. Under certain conditions COP-coats have been localized to special domains of the transitional ER and to the cis side of the Golgi complex. This led to the assumption that COP-coated vesicles are involved in export of proteins from the ER. In addition, new findings point to a function of COP-coated vesicles in back transport of proteins from the Golgi to the ER. At present it is not known whether COP-coated vesicles move only in one or in both directions between ER and Golgi.

【 授权许可】

Unknown