Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation

FEBS Letters

Takasaki, Ikuko²  Abeyama, Kazuhiro²  Nakajima, Toshihiro²  Kitajima, Isao²  Maruyama, Ikuro²  Kawano, Kazunori¹ 

[1] Department of Oral Radiology, Kagoshima University Dental School, 8-35-1 Sakuragaoka, Kagoshima City, Kagoshima 890, Japan;Department of Laboratory Medicine, Faculty of Medicine, Kagoshima University, Kagoshima City, Kagoshima 890, Japan

关键词: Ionizing radiation;    Differentiation;    Interleukin 6;    Nuclear factor κB;    Cell redox;   

DOI  :  10.1016/0014-5793(95)00412-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10–20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF-κB) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.

【 授权许可】

Unknown