The cytokine‐inducible zinc finger protein A20 inhibits IL‐1‐induced NF‐κB activation at the level of TRAF6

FEBS Letters

Heyninck, Karen¹  Beyaert, Rudi¹ 

[1] Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Ghent, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium

关键词: Gene expression;    Interleukin-1;    Nuclear factor κB;    TRAF6;    Zinc finger;   

DOI  :  10.1016/S0014-5793(98)01645-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1). Gene induction by IL-1 is mediated by activation of the transcription factor NF-κB, and requires the signal adapter protein TRAF6. The latter interacts with the NF-κB-inducing kinase NIK, which is believed to be part of the IκB kinase complex. Expression of A20 potently inhibits IL-1-induced NF-κB activation by an unknown mechanism. Inhibition of IL-1-induced NF-κB activation was found to be mediated by the C-terminal zinc finger-containing domain of A20. More importantly, we present evidence that A20 interferes with IL-1-induced NF-κB activation at the level of TRAF6, upstream of NIK. Moreover, A20 was shown to directly interact with TRAF6.

【 授权许可】

Unknown