Recombinant interferon‐β2 (interleukin‐6) induces myeloid differentiation

FEBS Letters

Chen, Louisa¹  Revel, Michel¹  Rubinstein, Menachem¹  Novick, Daniella¹ 

[1] Department of Virology, Weizmann Institute of Science, Rehovot, Israel

关键词: Growth control;    Leukemia;    Differentiation;    Interferon β2;    Interleukin 6;   

DOI  :  10.1016/0014-5793(88)80939-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human IFN-β2 cytokine produced in E. coli was purified to homogeneity by immunoaffinity and ion-exchange chromatography. The cytokine inhibits the growth of myeloleukemic M 1 cells and induces their morphological and functional differentiation into macrophages. Differentiation was also observed in the histiocytic lymphoma U937 cells. The effect on U937 was synergized by IFN-γ and under these conditions IFN-β2 produced the induction of (2′–5′) oligo(A) synthetase typical to IFN action and to differentiation.

【 授权许可】

Unknown