The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11–q12 and mouse chromosome 14 and has plant and nematode homologs

FEBS Letters

Apte, Suneel S.³  Seldin, Michael F.¹  Mattei, Marie-Genevieve²  Olsen, Bjorn R.³ 

[1] Department of Medicine, Duke University School of Medicine, Box 3380, Durham, NC 27710, USA;Hopital d'Enfants, INSERM U 406, Groupe Hospitalier de la Timone, 13385 Marseille Cedex 5, France;Department of Cell Biology, Harvard Medical School, 25 Shattuck St., Boston, MA 02115, USA

关键词: Cell death;    Apoptosis;    Programmed cell death;    Chromosome 14;    DAD1;   

DOI  :  10.1016/0014-5793(95)00321-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have cloned the cDNA encoding the mouse DAD1 (defender against apoptotic cell death) protein. While showing an expected high homology with the previously cloned human and Xenopus DAD1-encoding cDNAs, this sequence has striking homology to partial cDNA sequences reported from O. sativa (rice) and C. elegans (nematode), suggesting the existence of plant and invertebrate homologs of this highly conserved gene. The human and mouse DAD1 genes map to chromosome 14q11–q12 and chromosome 14, respectively. This mapping data supports and extends the previously reported similarities between human chromosome 14q and mouse chromosome 14.

【 授权许可】

Unknown