The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor

FEBS Letters

Oliverio, Serafina¹  Lentini, Alessandro¹  Autuori, Francesco¹  Piacentini, Mauro¹  Dini, Luciana¹ 

[1] Department of Biology, University of Rome ‘Tor-Vergata’, Rome, Italy

关键词: Programmed cell death;    Apoptosis;    Liver phagocytosis;    Cell turnover;   

DOI  :  10.1016/0014-5793(92)80373-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Apoptosing cells are actively phagocytosed in parenchymal tissues, thus preventing the inflammatory reaction which could derive from their slow uncontrolled degradation. The molecular mechanisms by which an apoptotic cell is recognized and taken up are largely unknown. We propose that the recognition of apoptotic hepatocytes is mediated by the sugar recognition systems of the liver, particularly the asialoglycoprotein receptor (ASGP-R). The results presented here demonstrate the participation of ASGP-R in the removal of apoptotic parenchymal cells, and indicate a new perspective for the understanding of its physiological role.

【 授权许可】

Unknown