Myogenin binds to and represses c‐fos promoter

FEBS Letters

Trouche, Didier¹  Robin, Philippe¹  Harel-Bellan, Annick¹  Masutani, Hiroshi¹  Groisman, Regina¹  Lenormand, Jean-Luc² 

[1] Laboratoire de Biologie des Tumeurs Humaines, CNRS URA 1156, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France;Laboratoire d'Oncologie Moléculaire, CNRS URA 1967, Institut Gustave Roussy, Villejuif, France

关键词: Myogenin;    c-fos;    Serum response element;   

DOI  :  10.1016/0014-5793(95)00140-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Myogenin (a member of the myogenic basic helixloop-helix transcription factor family) seems to be the main effector of proliferation repression, a crucial step which precedes muscle cell terminal differentiation during muscle development. Proliferation repression most likely occurs through inhibition of proliferation-associated genes such as the proto-oncogene, c-fos. Here, we demonstrate that myogenin binds to an E-box located in the main element of the c-fos promoter, the serum response element (SRE). Results from co-transfection experiments indicate that myogenin acts as a repressor for the SRE. Our data suggest that myogenin could play a role in c-fos inhibition at the onset of muscle cell terminal differentiation.

【 授权许可】

Unknown