FEBS Letters | |
Myogenin binds to and represses c‐fos promoter | |
Trouche, Didier1  Robin, Philippe1  Harel-Bellan, Annick1  Masutani, Hiroshi1  Groisman, Regina1  Lenormand, Jean-Luc2  | |
[1] Laboratoire de Biologie des Tumeurs Humaines, CNRS URA 1156, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France;Laboratoire d'Oncologie Moléculaire, CNRS URA 1967, Institut Gustave Roussy, Villejuif, France | |
关键词: Myogenin; c-fos; Serum response element; | |
DOI : 10.1016/0014-5793(95)00140-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Myogenin (a member of the myogenic basic helixloop-helix transcription factor family) seems to be the main effector of proliferation repression, a crucial step which precedes muscle cell terminal differentiation during muscle development. Proliferation repression most likely occurs through inhibition of proliferation-associated genes such as the proto-oncogene, c-fos. Here, we demonstrate that myogenin binds to an E-box located in the main element of the c-fos promoter, the serum response element (SRE). Results from co-transfection experiments indicate that myogenin acts as a repressor for the SRE. Our data suggest that myogenin could play a role in c-fos inhibition at the onset of muscle cell terminal differentiation.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020300818ZK.pdf | 590KB | download |