The widely used anesthetic agent propofol can replace α‐tocopherol as an antioxidant

FEBS Letters

Aarts, Leon¹  Bast, Aalt²  de Jong, Jan²  Langemeijer, Han¹  van der Hee, Regine²  Dekker, Ingrid² 

[1] Department of Anesthesiology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands;Leiden/Amsterdam Center for Drug Research, Division of Molecular Pharmacology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

关键词: Lipid peroxidation;    α-Tocopherol;    Glutathione;    Propofol;    Antioxidant;   

DOI  :  10.1016/0014-5793(94)01337-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the lipid soluble α-tocopherol. The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to α-tocopherol, since it also contains a phenolic OH-group. The transient protection of GSH against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α-tocopherol. Introducing propofol (2 and 5 μM) restored the protective effect of GSH. Similar to the control microsomes the GSH-protective effect did not occur in previously heated microsomes. These results suggest that propofol acts similarly to α-tocopherol as a chain breaking antioxidant in liver microsomal membranes.

【 授权许可】

Unknown