FEBS Letters | |
The widely used anesthetic agent propofol can replace α‐tocopherol as an antioxidant | |
Aarts, Leon1  Bast, Aalt2  de Jong, Jan2  Langemeijer, Han1  van der Hee, Regine2  Dekker, Ingrid2  | |
[1] Department of Anesthesiology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands;Leiden/Amsterdam Center for Drug Research, Division of Molecular Pharmacology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands | |
关键词: Lipid peroxidation; α-Tocopherol; Glutathione; Propofol; Antioxidant; | |
DOI : 10.1016/0014-5793(94)01337-Z | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the lipid soluble α-tocopherol. The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to α-tocopherol, since it also contains a phenolic OH-group. The transient protection of GSH against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α-tocopherol. Introducing propofol (2 and 5 μM) restored the protective effect of GSH. Similar to the control microsomes the GSH-protective effect did not occur in previously heated microsomes. These results suggest that propofol acts similarly to α-tocopherol as a chain breaking antioxidant in liver microsomal membranes.
【 授权许可】
Unknown
【 预 览 】
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