FEBS Letters | |
Flavonoids can replace α‐tocopherol as an antioxidant | |
van der Vijgh, Wim J.F.2  Bast, Aalt3  Schouten, Olga1  van Acker, Frédérique A.A.2  Haenen, Guido R.M.M.3  | |
[1] LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands;Department of Medical Oncology, BR-232, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;Department of Pharmacology and Toxicology, University Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands | |
关键词: Lipid peroxidation; α-Tocopherol; Glutathione; Flavonoid; Antioxidant; Free radical reductase; | |
DOI : 10.1016/S0014-5793(00)01517-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate α-tocopherol via a so-called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of α-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.
【 授权许可】
Unknown
【 预 览 】
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