Flavonoids can replace α‐tocopherol as an antioxidant

FEBS Letters

van der Vijgh, Wim J.F.²  Bast, Aalt³  Schouten, Olga¹  van Acker, Frédérique A.A.²  Haenen, Guido R.M.M.³ 

[1] LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands;Department of Medical Oncology, BR-232, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;Department of Pharmacology and Toxicology, University Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands

关键词: Lipid peroxidation;    α-Tocopherol;    Glutathione;    Flavonoid;    Antioxidant;    Free radical reductase;   

DOI  :  10.1016/S0014-5793(00)01517-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate α-tocopherol via a so-called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of α-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.

【 授权许可】

Unknown