Interleukin‐10 and pentoxifylline inhibit C‐reactive protein‐induced tissue factor gene expression in peripheral human blood monocytes

FEBS Letters

Bridey, F.¹  Ramani, M.¹  de Prost, D.¹  Hakim, J.¹  Khechai, F.¹  Ternisien, C.¹  Ollivier, V.¹ 

[1] INSERM U294 and Service d'hématologie et d'immunologie biologiques, CHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France

关键词: Monocyte;    Tissue factor;    C-reactive protein;    Interleukin-10;    Pentoxifylline;   

DOI  :  10.1016/0014-5793(94)01236-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fibrin deposition is an integral feature of the inflammatory response. In response to C-reactive protein (CRP), an acute-phase reactant, blood monocytes synthesize and express tissue factor (TF), the main initiator of blood coagulation. We report the inhibitory effect of interleukin 10 (IL-10) and that of pentoxifylline, a methyl xanthine derivative, on monocyte expression of TF activity, TF protein and TF mRNA in response to CRP. These agents may be of use in diseases where a TF-induced prothrombotic state is detrimental.

【 授权许可】

Unknown