Interleukin‐10 inhibits endotoxin‐induced tissue factor mRNA production by human monocytes

FEBS Letters

Bridey, F.¹  Ramani, M.¹  de Prost, D.¹  Khechai, F.¹  Ternisien, C.¹  Vu, T.¹  Ollivier, V.¹ 

[1] INSERM U294 and Service d'Hèmatologie et d'Immunologie biologiques, CHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France

关键词: Tissue factor;    Interleukin-10;    Monocyte;    Endotoxin;   

DOI  :  10.1016/0014-5793(93)81693-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate.

【 授权许可】

Unknown