期刊论文详细信息
FEBS Letters | |
Neuromedin B receptor, expressed in Xenopus laevis oocytes, selectively couples to Gαq and not Gα11 | |
Lipinsky, Dafna2  Battey, James F.1  Shapira, Hagit2  Oron, Yoram2  Way, James1  | |
[1] Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, USA;Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel | |
关键词: G-protein; Neuromedin B receptor; Gastrin-releasing peptide receptor; Xenopus oocyte; | |
DOI : 10.1016/0014-5793(94)00570-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
G-proteins of the q family have been implicated as mediators of bombesin receptors action. We cloned Xenopus Gαq and Gα11 and specifically disrupted the synthesis of either protein with selective antisense oligonucleotides. Gαq antisense inhibited responses mediated by neuromedin B receptor (NMB-R) by 74%, though not by gastrin-releasing peptide receptor (GRP-R). Gα11 antisense had little effect on either GRP-R- or NMB-R-mediated responses. This suggests that NMB-R couples to Gαq, and that GRP-R and NMB-R show distinct G-protein coupling preferences in the Xenopus oocyte.
【 授权许可】
Unknown
【 预 览 】
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RO201912020299726ZK.pdf | 519KB | download |