Calcium, calmodulin and cell cycle regulation

FEBS Letters

Means, Anthony R.¹ 

[1] Department of Pharmacology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA

关键词: Calcium;    Calmodulin;    Cell cycle;    Protein kinase;    Protein phosphatase;   

DOI  :  10.1016/0014-5793(94)00492-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Calcium and its ubiquitous intracellular receptor calmodulin are required for cell proliferation. Studies in a variety of model systems are beginning to identify components of the calcium/calmodulin cascade required for movement of quiescent cells into the cell cycle as well as for proliferating cells to move from G₁ to S, G₂ to M and through mitosis. Two calcium/calmodulin-dependent enzymes, the multifunctional calcium/calmodulin-dependent protein kinase and the protein phosphatase 2B (calcineurin) as well as a spindle pole body protein that binds calmodulin in the absence of calcium have been shown to be essential at specific phases of the cell cycle. In addition, the status of the intracellular calcium pools is critical for normal traverse of the cell cycle.

【 授权许可】

Unknown