Organisation of the murine 5‐HT3 receptor gene and assignment tohuman chromosome 11

FEBS Letters

Rappold, Gudrun¹  Villarroel, Alfredo²  Abdelatty, Fawzy²  Koenen, Michael²  Weiss, Birgit¹  Uetz, Peter² 

[1] Institut für Humangenetik und Anthropologie Universität Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany;Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Jahnstr. 29, D69120 Heidelberg, Germany

关键词: Serotonin;    Gene structure;    Alternative splicing;    Mouse brain;    Exon alignment;   

DOI  :  10.1016/0014-5793(94)80435-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have isolated the murine gene encoding the 5-HT₃ receptor (5-HT₃R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT₃R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5-HT₃R variants. The 5-HT₃R gene, whose structure is closely related to neuronal and muscle AChRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.

【 授权许可】

Unknown